Antibody-drug conjugates (ADCs) represent a rapidly growing class of anti-cancer therapeutics in which a potent small molecule is linked to a monoclonal antibody.
To-date, two antibody-drug conjugate…

Antibody-drug conjugates (ADCs) represent a rapidly growing class of anti-cancer therapeutics in which a potent small molecule is linked to a monoclonal antibody.

To-date, two antibody-drug conjugates have been approved by regulators in the United States, Canada and Europe. These two modalities conjugate the cytotoxic drugs to either lysine or cysteine after reduction of four inter-chain disulfide bonds.

Due to the (1) small molecule property, the (1) chemical linking chemistry and (3) different amino acid conjugation, antibody-drug conjugates or ADCs exhibits a more complex and heterogeneous structure than the parent monoclonal antibody.

This complexity and heterogeneity present a significant challenge.

However, analytical characterization plays a crucial role during discovery, process scale-up, manufacturing, and release/stability testing of antibody-drug conjugates. This includes the determination of drug-to-antibody ratios (DAR) and sites of conjugation.

Hence, the selection of appropriate analytical techniques, which depends on the properties of the linker, the drug and the choice of attachment site, is critical.

Biochempeg giving full support to make their research in ADC more convenient and diverse, which has developed a series of peptides with discrete PEG chain which mitigates aggregation & immunogenicity in ADC.

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ABOUT THE AUTHOR

The editorial team of ADC Review | Journal of Antibody-drug Conjugates (ISSN 2327-0152) consists of an Editor-in-Chief, Deputy Editors, and Consulting Editors. Members of the editorial team are chosen based on their demonstrated expertise in one or more areas of oncology or hematology and their active engagement in research, the development, manufacturing and clinical application of antibody-drug conjugates (ADCs).